有人表情特別豐富，說話時總揚著深深的抬頭紋，令人留下粗獷性格的印象。不過，一項法國研究警告，這些深深的抬頭紋可能是心血管疾病的早期徵兆。
據《每日郵報》（DailyMail）與《獨立報》（The Independent）26日報導，這份在歐洲心臟學會（European Society of Cardiology，ESC）2018年會提出的研究報告指出，抬頭紋比同齡人多者，因心血管疾病死亡的機率也比較高。
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